Stable, highly concentrated fluoro carbon emulsions

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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424 9, 1286534, 436173, 514169, 514171, 514460, 514744, 514757, 514832, 514937, 514941, 514943, A61K 4904, A61K 3156, A61K 3135, A61B 5055

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053935136

ABSTRACT:
A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement medium capable of facilitating the detection of tumors and other elements within the body. This emulsion is stable and maintains its very small particle size characteristics for extended periods of time, often exceeding eighteen months after sterilization, and further may include a stabilizing component selected from the group consisting of steroids, tocopherols, cholesterols, and combinations thereof. An anti-oxidizing component enhances delivery in oxygen transport.

REFERENCES:
patent: 3818229 (1974-06-01), Long, Jr.
patent: 3958014 (1976-05-01), Watabe et al.
patent: 3975512 (1976-08-01), Long
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4105798 (1979-08-01), Moore et al.
patent: 4146499 (1979-03-01), Rosano
patent: 4397870 (1983-08-01), Sloviter
patent: 4450481 (1984-05-01), Osterholm
patent: 4917930 (1990-03-01), McCormick
Beisbarth, H. and T. Suyama, 5th Intl. Symp. on Perfluorochemical Blood Substitutes. Mainz: Mar. 1981.
Persico, D. et al., A General Systhesis for Symmetrical Highly Branched Perfluoro Ethers J. Org. Chem. 50:5156-5169 (1985).
Sharts, C. and H. Reese, The Solubility of Oxygen in Aqueous Flurocarbon Emulsions. J. Fluorine Chemistry 11:637-641 (1978).
S. Davis, 2nd International Symposium on Clinical Nutrition Advances in Clinical Nutrition 19:213-239, Bermuda: May 1982.
Yokoyama, K. et al., Preparatiion of Perfluorodecalin Emulsion, and Approach to the Red Cells Substitute, Fed. Proc. 34(6) 1478-1483 (1975).
Steiner, M. and J. Anastasi, J. Clinical Investigation 57:732-737 (1976).
Pandolfe, W. D. and R. R. Kinney, "Recent Developments in the Understanding of Homogenization Parameters" Denver, Colo. Aug. 29, 1983.
Chandonnet, S. et al., Preparation of Microemulsions by Microfluidization, Feb. 1985.
Korstvedt, H. et al., Microfluidization: for Making Fine Emulsions and Dispersions, Amer. Paint and Coatings Journal, Jan. 28, 1985.
Korstvedt, H. et al., Microfluidization, Drug and Cosmetic Industry, Nov. 1984.
Allinger, H., Ultrasonic Disruption, American Laboratory, Oct. 1985.
Berlinger, S. Application of Ultasonic Processors, Biotechnology Laboratory, Mar. 1984.
Gould, S. et al., Assessment of a 35% Fluorocarbon Emulsion, The Journal of Trauma 23(8):720-724 1983.
Police, A. M. et al., Critical Care Medicine 13(2):96-98 1985.
Nunn, G. R. et al., Effect of Fluorocarbon Exchange Tranfusion on Myocardial Infarction Size in Dogs, American J. of Cardiology 52:203-205 1983.
Bose, B. et al., Brain Research 328:223-231 1985.
Spears, J. et al., Circulation (Abstracts) 68 (Supp. III) No. 317 Oct. 1983.
Patel, M. et al., Survival and Histopathological Changes in Lungs of Hamsters following Liquid Synthetic Breathing Fed. Proceedings 29(5):1740-1745 1970.
A Technical Bulletin #67 of the Fauling Corporation Sep. 1982 Peck, W. W. et al., Investigative Radiology 19:129 1984.
Gaulin Corp. A Technical Bulletin #67, Sep. 1982.
Dobben, G. et al., Experimenta Studies with Radiopaque Fluorocarbon in the Subarchnoid Space, Neuroradiology 6:17-19 1973.
Brahme, F. et al., Investigative Radiology 11(4):319-330 1976.
Long, D. M. et al., Radiology 105(2):323-332 1972.
Riess, Jean, Artificial Organs 8:34-56 1984.

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