Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1989-06-14
1990-10-30
Warren, Charles F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 711, 4351723, 435320, 4352523, C12P 2100, C12N 1500, C12N 120
Patent
active
049668404
ABSTRACT:
DNA plasmids are described which are selected mutants in which an altered repressor gene leads to high copy number replication. Elements in the plasmids are modified in such a way that readthrough expression of heterologous DNA inserted in the plasmid will not continue into the replication primer strand. Deletions resulting from interference with replication primer strand transcription are thereby avoided.
REFERENCES:
patent: 4237224 (1980-12-01), Cohen et al.
patent: 4322499 (1982-03-01), Baxter et al.
patent: 4374927 (1983-02-01), Sninsky et al.
patent: 4631257 (1986-12-01), Gelfand
Shepard et al., "Cell", vol. 18, pp. 267-275, Oct. 1979.
Felipe Cabello, et al., Replication Control in a Composite Plasmid Constructed by in vitro Linkage of Two Distinct Replica, "Nature", 259:285-290 (1976).
Barry Polisky, et al., A Plasmid Cloning Vehicle Allowing Regulated Expression of Eukaryotic DNA in Bacteria, "PNAS", U.S.A. 73:3900-3904 (1976).
Reiner Gentz, et al., Cloning and Analysis of Strong Promoters is Made Possible by the Downstream Placement of a RNA Termination Signal, "PNAS", USA 78:4936-4940 (1981).
E. Beck, et al., Nucleotide Sequence of Bacteriophage of DNA, "Nucleic Acids Research", vol. 5, No. 12, pp. 4495-4503 (1978).
So et al., 1975, Molecular Gen. Genet. 142:239-249.
Galau et al., 1976, Cell 7:487-505.
Heffron et al., 1977, in DNA Insertion Elements, Plasmids and Episomes, Bukhari et al., eds., Cold Spring Harbor Laboratory, pp. 161-167.
O'Farrell et al., 1978, J. of Bacteriology 134:645-654.
Gelfand et al., 1978, Proc. Natl. Acad. Sci. U.S.A. 75:5869-5873.
Uhlin et al., 1978, Molecular Gen. Genet. 165:167-179.
Ogura et al., 1978, Annu. Rep. Inst. Virus Res. 21:68-70.
Andreoli et al., 1978, J. Bacteriology 135:612-621.
Stueber et al., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:167-171.
Yamaguchi et al., 1980, Molecular Gen. Genet. 178:525-533.
Weisblum et al., 1979, J. of Bacteriology 137:635-643.
Itoh et al., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:2450-2454.
Twigg et al., 1980, Nature 283:216-218.
Conrad et al., 1979, Cell 18:61-71.
Muesing et al., 1981, Cell 24:235-242.
Tomizawa et al., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:1421-1425, 6096-6100.
Cetus Corporation
Halluin Albert P.
Low C.
McLaughlin Jane R.
Warren Charles F.
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