Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Blood gas standard or control
Patent
1992-06-11
1994-04-19
Housel, James C.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Blood gas standard or control
436 15, 436 16, 436 18, G01N 3349, G01N 33487, G01N 3300
Patent
active
053044916
ABSTRACT:
A stable reference solution for calibrating and monitoring blood gas instrumentation is disclosed. The solution comprises an aqueous mixture containing a hemoglobin solution derived from a mammalian source which comprises at least about 95% reduced hemoglobin. The solution additionally contains a metal catalyzed methemoglobin reducing system, reference concentrations of selected electrolytes and an organic buffer. To provide a control element having a variety of properties similar to fresh, whole, human blood, the reference solution is stored in a sealed ampule under an inert atmosphere containing CO.sub.2 until just prior to use. The ampule is subsequently opened and the solution is equilibrated with a gas mixture having components which provide gasses in a physiological range to the solution. The solution is characterized by exhibiting properties similar to fresh blood subsequent to equilibration and an extended storage life prior to equilibration.
REFERENCES:
patent: 3973913 (1976-08-01), Louderback
patent: 4199471 (1980-04-01), Louderback et al.
patent: 4279775 (1981-07-01), Louderback et al.
patent: 4299728 (1981-11-01), Cormier et al.
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4469792 (1984-09-01), Simmonds et al.
patent: 4485174 (1984-11-01), Chiang et al.
patent: 4711852 (1987-12-01), Jacobson et al.
patent: 4753888 (1988-06-01), Chiang
patent: 4843013 (1989-06-01), Chiang
patent: 4945062 (1990-07-01), Chiang
patent: 5013666 (1991-05-01), Chiang
patent: 5045529 (1991-09-01), Chiang
Sprokholt, R. and Maas, A. H. J., Physiology and Methodology of Blood Gasses and pH, vol. 4: IFCC Workshop Oslo, 67-97 (1984).
Mansouri, A., Hemoglobin, 5(6): 579-589 (1981).
Mesukawa, T. and Iwats, H., Life Science, 21:695-700 (1977).
Chauntin, A. and Curnish, R., Archives of Biochemistry and Biophysics, 121: 96-102 (1967).
Benesch, R. and Benesch, R. E., Nature, 221: 618-622 (1969).
International Search Report dated 28 Jun. 1990 for corresponding PCT application PCT/US90/01422.
Feola et al., Surgery, Gynecology & Obstetrics 157(5) 399-408 (Nov. 1983).
Chiang Ching
Liffmann Stanley M.
Bhat N.
Bionostics, Inc.
Housel James C.
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