Stable growth transformation of human T-lymphocytes by Herpesvir

Details Stable growth transformation of human T-lymphocytes by Herpesvir Stable growth transformation of human T-lymphocytes by Herpesvir

1995-04-27

1997-09-23

Guzo, David

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352402, 4353201, C12N 510, C12N 1563, C12N 1564

Patent

active

056703520

ABSTRACT:
The invention concerns the transformation of human T-lymphocytes to stable growth by infecting said T-cells with strains of H. saimiri subgroup NonA NonB, preferably subgroup C. The transformed cells grow independently of antigen stimulation and can have a phenotype of activated mature T-lymphocytes, expressing cell surface markers characteristic for the distinct differentiation status of the T-cells. Infection with strains of H. saimiri belonging to the subgroups above can thus be used to generate human T-cell lines for a variety of immunological and biochemical applications as well as for therapeutic use.

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