Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1992-10-30
1994-11-22
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
514 2, 514 8, 514 12, 530350, 530395, 530806, 530855, 435 693, 4352523, 43525233, 4353201, 536 231, 536 234, 4242661, A61K 3900, C12N 1512, C07K 900, C07K 1508
Patent
active
053667280
ABSTRACT:
Stable forms of Taenia ovis peptide antigens, such as portions of a T. ovis oncosphere antigen which runs as a 47-52 kDa doublet, are suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obtained by isolation and expression of the DNA encoding them in recombinant host cells. Aspects of the invention include DNA encoding T. ovis antigens, vectors containing such DNA and host cells which express the T. ovis antigens.
REFERENCES:
patent: 5192538 (1993-03-01), Harrison et al.
Howell, M. J. et al. "Cloning and expression of Taenia ovis antigens . . . ", Mol. & Biochemical Parasitology 28 (1988), pp. 21-30.
Johnson, K. S. et al. "Vaccination against ovine cysticerosis . . . " Nature, vol. 338, 13 Apr. 1989, pp. 585-587.
Bowtell, D. D. L., et al., Parasitology 93:599-610 (1986), "Immunochemical analysis of Taenia taeniaeformis antigens expressed in Escherichia coli,".
Cougle W. G., et al., Mol. and Biochem. Parasitol. 45:137-146 (1991), "Molecular cloning of Taenia taeniaeformis onocosphere antigen genes".
Heath, D. D., et al., J. Parasitol 71(2):192-199 (1985), "The use of excretory y antigens of the scolex of Tenia ovis for the serodiagnosis of infection in dogs".
Howell, M. J., et al., Mol. and Biochem. Parasitol. 28:21-30 (1988), "Cloning and expression of Taenia ovis antigens in Escherichia coli".
Howell, M. J., et al., Int. J. for Parasitol. 19(6):631-638 (1989), "Characterization of cloned antigens of Taenia ovis".
Johnson, K. S., et al., Nature 338:585-587 (13 Apr. 1989), "Vaccination against ovine cysticerosis using a defined recombinant antigen".
Osborn, P. J., et al., Res. in Veterin. Sci. 32:351-353 (1982), "Vaccination of sheep against Taenia ovis. The response to various dose rates of antigens obtained by incubation of oncosphered in vitro,".
Rickard, M. D., et al., Parasitology 75:183-188 (1977), "Vaccination of lambs against infection with Taenia ovis using antigens collected furing short-term in vitro incubation of activated T. ovis oncospheres".
Rickard, M. D., et al., Australian Veterin. J. 52:209-215 (1976), "Vaccination of lambs against infection with Taenia ovis".
Dempster Robert P.
Harrison Gavin B. L.
Heath David D.
Lawrence Stephen B.
Lightowlers Marshall W.
Cunningham T.
Her Majestry the Queen in right of New Zealand through the Minis
Nucker Christine M.
Pitman-Moore New Zealand Limited
The University of Melbourne
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