Stable expression of human A.sub.2B adenosine receptors, and ass

Details Stable expression of human A.sub.2B adenosine receptors, and ass Stable expression of human A.sub.2B adenosine receptors, and ass

1996-06-20

1998-12-29

Spector, Lorraine

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436504, 435 691, 435 697, 4353201, 435325, 530350, G01N 33566

Patent

active

058540814

ABSTRACT:
Stable over-expression of native and hexahistidine/FLAG extended recombinant human adenosine receptors permits recovery of membranes and membrane fragments bearing a high density of adenosine receptors. Cell lines expressing all four sub-types of human adenosine receptors have been identified. The receptors, and membranes and membrane fragments bearing the same, can be used in assays to screen compounds for binding ability to the adenosine receptors, such as potential pharmaceutical agents.

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Nilsson et al., Journal of Molecular Recognition 9 (5-6):585-594 1996.

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