Stable epimerase reagent, cyclase reagent and ring expansion rea

Details Stable epimerase reagent, cyclase reagent and ring expansion rea Stable epimerase reagent, cyclase reagent and ring expansion rea

1983-06-27

1985-08-20

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 43, 435 47, 435 49, 435189, 435190, 435191, 435814, 435815, 435816, 435886, C12N 900, C12N 906, C12P 3700, C12P 3500

Patent

active

045364761

ABSTRACT:
Cyclase, epimerase and a ring expansion enzyme are isolated separately from a cell free extract of a prokaryotic beta-lactam producing organism to provide three separate and stable enzyme reagents for commercial production of cephalosporins from peptide precursors. Isolation is carried out by using ammonium sulfate, gel filtration and ion exchange chromatography. The enzymes may be immobilized on a suitable support and the production of cephalosporins may be carried out continuously.

REFERENCES:
patent: 4075061 (1978-02-01), Fleming et al.
patent: 4178210 (1979-12-01), Demain et al.
patent: 4248966 (1981-02-01), Demain et al.
patent: 4307192 (1981-12-01), Demain et al.

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