Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai
Patent
1996-05-23
1997-06-03
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Halogenated hydrocarbon doai
514311, 514747, 514749, 514756, A61K 3102, A61K 3147, A61K 31025, A61K 3103
Patent
active
056355394
ABSTRACT:
Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly soluble in water, a surfactant and water.
REFERENCES:
patent: 2055083 (1936-09-01), Klein et al.
patent: 3778381 (1973-12-01), Rosano et al.
patent: 3793450 (1974-02-01), Schnell
patent: 3823091 (1974-07-01), Samejima et al.
patent: 3911138 (1975-10-01), Clark, Jr.
patent: 3914294 (1975-10-01), Bernstein et al.
patent: 3942527 (1976-03-01), Li
patent: 3958014 (1976-05-01), Watanabe et al.
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 3975512 (1976-08-01), Long, Jr.
patent: 3989843 (1976-11-01), Chabert et al.
patent: 3993581 (1976-11-01), Yokoyama et al.
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4073943 (1978-02-01), Wretlind et al.
patent: 4105798 (1978-08-01), Moore et al.
patent: 4110474 (1978-08-01), Lagow et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4252827 (1981-02-01), Yokoyama et al.
patent: 4285928 (1981-08-01), Wada et al.
patent: 4325972 (1982-04-01), Geyer et al.
patent: 4366169 (1982-12-01), White
patent: 4395393 (1983-07-01), Schmolka
patent: 4397870 (1983-08-01), Sloviter
patent: 4423061 (1983-12-01), Yokoyama et al.
patent: 4423077 (1983-12-01), Sloviter et al.
patent: 4425347 (1984-01-01), Yokoyama et al.
patent: 4443480 (1984-04-01), Clark, Jr.
patent: 4446154 (1984-05-01), Osterholm
patent: 4452818 (1984-06-01), Haidt
patent: 4461717 (1984-07-01), Moore
patent: 4486417 (1984-12-01), Sugimoto et al.
patent: 4497829 (1985-02-01), Sloviter
patent: 4526969 (1985-07-01), Yokoyama et al.
patent: 4534978 (1985-08-01), Yokoyama et al.
patent: 4542147 (1985-09-01), Yokoyama et al.
patent: 4562183 (1985-12-01), Tatlow et al.
patent: 4569784 (1986-02-01), Moore
patent: 4591599 (1986-05-01), Yokoyama et al.
patent: 4599343 (1986-07-01), Yokoyama et al.
patent: 4657532 (1987-04-01), Osterholm
patent: 4866096 (1989-09-01), Schweighardt
patent: 4895876 (1990-01-01), Schwighardt et al.
patent: 5171755 (1992-12-01), Kaufman et al.
patent: 5514720 (1996-05-01), Clark, Jr. et al.
L.C. Clark et al, "Emulsions of Perfluorinated Solvents for Intravascular Gas Transport", Fed.Proc., 34, pp. 1468-1477 1975.
R. Jeppsson, "Comparison of Pharmacological Effects of Some Local Anaesthetic Agents when using Water and LIpid Emulsion as Injection Vehicles", Acta Pharmacol. et Toxicol., 36 pp. 299-311 1975.
R. Jeppsson, "Parabolic Relationship between Lipophilicity and Biological Activity of Aliphatic Hydrocarbons, Ethers and Ketones after Intravenous Injections of Emulsion Formulations into Mice", Acta Pharmacol. et Toxicol., 37, pp. 56-64 1975.
R. Jeppsson, et al., "Anticonvulsant Activity in Mice of Diazepam in an Emulsion Formulation for Intravenous Administration", Acta Pharmacol. et Toxicol., 36 pp. 312-320 1975.
R. Jeppsson et al., "The Influence of Emulsifying Agents and of Lipid Soluble Drugs on the Fractional Removal Rate of Lipid Emulsions from the Blood Stream of the Rabbit", Acta Pharmacol. et Toxicol., 37, pp. 134-144 1975.
R. Jeppsson et al, "The Ultrastructure of Lipid Particles in Emulsions Prepared with Various Emulsifiers", Aust. J. Exp. Biol. Med. Sci., 52, pp. 697-702 1974.
R. Jeppsson et al. "Compatability of Parenteral Nutrition Solutions when mixed in a Plastic Bag", Clin. Nutr. 2, pp. 149-158 1974.
R. Jeppsson et al. "Particle Size Distribution of a Fluorochemical Emulsion", in Proceedings of the HS Symposium on Perfljuorochemicals in Medicine and Biology, Huddinge, Sweden, Apr. 28-29, V. Novakova et al., eds., pp. 108-113 1977.
S. Ljungberg et al. "Intravenous Injection of Lipid Soluble Drugs", Acta Pharm. Suecica, 7, pp. 435-440 1970.
H. Ohyanagi et al., "Development and Clinical Application of Perfluorochemical Artificial Blood", Int. J. Artificial Organs, 9, pp. 363-368 1986.
A. Wretlind, "Current Status of Intralipid and Other Fat Emulsions", in Fat Emulsions Parenter. Nutr., H.C. Meng et al., eds., American Medical Association, Chicago, IL, pp. 109-122 1976.
A. Wretlind, "Development of Fat Emulsions", J. Parenter. Enteral Nutr., 5, pp. 2301-2335 1981.
K. Yokoyama et al. "A Perfluorochemical Emulsion as an Oxygen Carrier", Artificial Organs, 8, pp. 34-40 1984.
Clark, Jr. Leland C.
Shaw Robert F.
Barnes Richard M.
HemaGen/PFC
Henley III Raymond
Marks Andrew S.
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