Stable emulsion suitable for pharmaceutical administration, the

Details Stable emulsion suitable for pharmaceutical administration, the Stable emulsion suitable for pharmaceutical administration, the

1993-05-06

1996-03-05

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142262, 514523, 514786, 5142248, A61K 3154, A61K 31275

Patent

active

054968186

ABSTRACT:
A stable active substance emulsion of the oil-in-water type with a phospholipid as emulsifier is described, where the active substance dissolved in the lipid phase has one or more basic groups, is hydrophobic and oil-soluble, and has a pKa of at least 7.5, the aqueous phase is set at an acid pH, and the disperse phase gives a positive zeta potential of at least +15, but preferably +30, mV after dilution of the emulsion ready for administration to a fat content of 0.08% by weight.

REFERENCES:
patent: 4777183 (1988-10-01), Lenke et al.
patent: 4816247 (1989-03-01), Desai et al.
patent: 4880634 (1989-11-01), Speiser
patent: 5364632 (1994-11-01), Benita et al.

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