Stable, effervescent vaginal suppositories

Details Stable, effervescent vaginal suppositories Stable, effervescent vaginal suppositories

1987-10-28

1989-08-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Gas produced in situ by chemical reaction

424 78, 514718, 514967, A61K 3174

Patent

active

048532118

ABSTRACT:
An effervescent vaginal suppository composition containing a stabilizer appropriately selected from the group consisting of anhydrous sodium sulfate, anhydrous silica gel, dried magnesium silicate, dried aluminum silicate, dried calcium carboxymethylcellulose, dried microcrystalline cellulose, dried starch and dried calcium phosphate or mixtures thereof, preferably in an amount of 0.1-20% based on the weight of said effervescent vaginal suppository composition. Shaped effervescent vaginal suppositories are produced therefrom.

REFERENCES:
patent: 3062715 (1962-11-01), Reese
patent: 4187286 (1980-02-01), Marcus
patent: 4288438 (1981-09-01), Kubo et al.
patent: 4322399 (1982-03-01), Ahmad et al.
patent: 4323548 (1982-04-01), Scherm
Gregory, Use & Applications, p. 558, (1939).
Remington's Pham. Sciences, 16th Ed., p. 1555, (1980).
Remington's Pharm. Sciences, pp. 384-385, (1975).
Physician's Desk Reference (PDR), p. 1636, (1976).
Handbook of Nonprescription Drugs, 6th Ed., p. 50, (1979).

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