Stable diagnostic reagent and method for qualitative determinati

Details Stable diagnostic reagent and method for qualitative determinati Stable diagnostic reagent and method for qualitative determinati

1979-08-17

1982-05-11

Turk, Arnold

Chemistry: physical processes

Physical processes

Crystallization

23915, 424 12, G01N 3354

Patent

active

043291511

ABSTRACT:
A method and a stable reagent for the detection of pathogenic bacterial infections in humans, and in particular, a stable diagnostic composition comprising non-degraded streptolysin-O protein directly adsorbed onto polystyrene latex particles and method of use are disclosed. The reagent may be prepared by adsorbing one or more layers of the streptolysin-O toxin onto the surface of the latex particle, effecting an intermolecular cross-linkage of the streptolysin-O, and further stabilizing the reagent by the addition of a bacteriostatic agent. Accordingly, the present invention provides a significant advance regarding the qualitative determinations of streptococci infections by providing a stable diagnostic reagent and method for such determinations.

REFERENCES:
patent: 3857931 (1974-12-01), Hager
patent: 3956477 (1976-05-01), Price et al.
patent: 3985867 (1976-10-01), Redshaw
patent: 4108974 (1978-08-01), Wegfahrt et al.
patent: 4181636 (1980-01-01), Fischer
Ramello et al., Archivio per le Scienze Mediche, 126, 390-392, 1969.
Ramello et al., "Determination of Anti-O-Streptolysin titer with Polystyrene Latex", Chemical Abstracts, vol. 73, No. 1975r, 1970.
Kumagai et al., "Reagents for Rapid Antistreptococcal Antibody Tests", Chemical Abstracts, vol. 80, No. 131627j, 1974.
Mosley et al., "BSSA: AN Agglutinogen for Quantitation of Antistreptolysin-O", Amer. Journal of Clincal Pathology, vol. 44, No. 5, Nov. 1965.

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