Stable cystal of protected pseudouridine

Details Stable cystal of protected pseudouridine Stable cystal of protected pseudouridine

2011-06-28

2011-06-28

McIntosh, III, Traviss C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S018700, C536S029200, C536S124000

Reexamination Certificate

active

07968521

ABSTRACT:
A stable and high-purity protected pseudouridine in crystal form is provided represented by the following structural formula:wherein M represents a trityl group or a derivative thereof, which is a useful material for producing an RNA oligomer or a similar substance. A method for producing the crystalline protected pseudouridine is also provided, which method includes crystallizing a protected pseudouridine from a solution containing the protected pseudouridine, by use of an ester solvent and/or an alcoholic solvent. The method, which does not need a silica gel column treatment, can be performed in a simple manner, does not impose a load on the environment, and realizes low-cost production of a target crystalline protected pseudouridine.

REFERENCES:
patent: 2-091022 (1990-03-01), None
patent: 2-104586 (1990-04-01), None
patent: 2-196787 (1990-08-01), None
patent: 96/018736 (1996-06-01), None
Pfister et al., Nucleosides, Part LIX, Helvetica Chimica Acta, 1995, vol. 78, No. 7, pp. 1705-1737.
Pfister, Magdalena et al., Nucleosides. Part LIX. The 2-(4-nitrophenyl) ethylsulfonyl (npes) group: A new type of protection in nucleoside chemistry, Helvetica Chimica Acta, 1995, vol. 78, No. 7, pp. 1705 to 1737, particularly, pp. 1709, 1723.
Agris, P.F. et al., Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry, Biochimie, 1995, vol. 77, No. 1/2, pp. 125 to 134, particularly, p. 128.
Yang, Zaiwan et al., Nucleic acid chemistry. V. Synthesis of modified ribonucleotides and oligonucleotides, Huaxue Xuebao, 1986, vol. 44, No. 11, pp. 1106-1112 (abstract) CAplus (online), AN 1987:637207, DN 107:237207.
European Search Report issued on Apr. 3, 2009, for corresponding Patent Application EP 06767085.1.

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