Stable cyanine dye phosphoramidites

Details Stable cyanine dye phosphoramidites Stable cyanine dye phosphoramidites

2007-06-12

2007-06-12

Powers, Fiona T. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C435S006120, C530S802000

Reexamination Certificate

active

10889821

ABSTRACT:
This invention provides dye phosphoramidites, particularly phosphoramidites of substituted cyclic bridged cyanine and related dyes, of the general formula:In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted aromatic ring; m is an integer from 1 to 18; Y and Z are independently selected from the group consisting of S, O, N, CH2and C(CH3)2; R1is an alkyl; (PAM) is a phosphoramidite group; X{circle around (−)}is a negative ion; and Q is L-W, wherein L is a conjugated cyclic moiety and W is OR2, wherein R2is a second alkyl. Methods of making and using the dye phosphoramidites are also provided.

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International Search Report, Jan. 13, 2006.

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