Stable crystals of substituted phenylpropionic acid...

Details Stable crystals of substituted phenylpropionic acid... Stable crystals of substituted phenylpropionic acid...

2007-10-09

2007-10-09

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C514S562000

Reexamination Certificate

active

10497174

ABSTRACT:
Preparation of (S)-2-[[3-[N-[4-[(4-fluorophenoxy)phenyl]methyl]carbamoyl]-4-methoxyphenyl]methyl]butanoic acid (referred to as compound (I)) on an industrial scale lies in the finding of crystals homogeneous and excellent in the stability and the establishment of a preparative process thereof.Novel crystals of compound (I) homogeneous and excellent in the stability characterized by exhibiting the diffraction angles (2θ) at at least 17.7°, 19.0° and 24.1° in the X-ray powder diffraction are provided by recrystallizing from an alcoholic solvent and purifying by acid-base treatment.

REFERENCES:
patent: 6506797 (2003-01-01), Nomura et al.
patent: 2 376 094 (2000-12-01), None
patent: 00/75103 (2000-12-01), None
patent: 01/21578 (2001-03-01), None
patent: 01/25181 (2001-04-01), None
Laszlo Borka, et al., “Crystal polymorphism of pharmaceuticals”, Acta Pharm. Jugosl., vol. 40, XP-009031944, 1990, pp. 71-94.

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