Stable compositions of gastroprotected omerprazole microgranules

Details Stable compositions of gastroprotected omerprazole microgranules Stable compositions of gastroprotected omerprazole microgranules

1993-06-16

1995-01-31

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424458, 424461, 424462, 424490, 424493, 424497, A61K 954, A61K 962

Patent

active

053857399

ABSTRACT:
The present invention relates to a stable formulation of omeprazole microgranules containing a neutral core consisting of sugar and starch, characterized in that it contains an active layer consisting of a dilution of omeprazole in mannitol in substantially equal amounts. It also relates to a process for producing such formulations.

REFERENCES:
patent: 4255431 (1979-04-01), Junggren et al.
patent: 4840799 (1989-06-01), Appelgren et al.
Omeprazole, A Survey of Preclinical Data, The Scandinavian Journal of Gastroenterology, 1985, 113-120, Cederberg.
Acta Chemica Scandinavia, 43 (1989), 536-548 (Arne Brandstrom et al.).

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