Stable compositions containing OMVs

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S250100

Reexamination Certificate

active

07820185

ABSTRACT:
An OMV preparation comprises OMVs having a sufficiently positive or negative surface charge to substantially prevent aggregation.

REFERENCES:
patent: 7179484 (2007-02-01), Singh
patent: 2003/0138453 (2003-07-01), O'Hagan et al.
patent: 0 301 992 (1989-02-01), None
patent: 0 624 376 (1994-11-01), None
patent: WO 92/05194 (1992-04-01), None
patent: WO 01/09350 (2001-02-01), None
patent: WO 01/91788 (2001-12-01), None
patent: WO 03/051379 (2003-06-01), None
patent: WO 2004/019977 (2004-03-01), None
Haake, et al.; Characterization of the Leptospiral Outer Membrane and Description of Three Novel Leptospiral Membrane Proteins; Infection and Immunity, Sep. 2002, vol. 70, No. 9; pp. 4936-4945.
Arigita, et al.; Stability of Mono- and Trivalent Meningococcal Outer Membrane Vesicle Vaccines; Vaccine vol. 22, No. 5-6; Jan. 26, 2004; pp. 629-643. XP004485193.
Arigita, et al.; Restored Functional Immunogenicity of Purified Meningoccal PorA by Incorporation Into Liposomes; Vaccine vol. 21, No. 9-10; Feb. 14, 2003; pp. 950-960. XP004402623.
Van Der Ley, et al.; Construction ofNeisseria meningitidisStrains Carrying Multiple Chromosomal Copies of the PorA Gene for Use in the Production of a Multivalent Outer Membrane Vesicle Vaccine; Vaccine 1995, vol. 13, No. 4; pp. 401-407. XP004057740.

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