Stable composition of S-adenosyl-L-methionine

Details Stable composition of S-adenosyl-L-methionine Stable composition of S-adenosyl-L-methionine

1980-11-20

1983-01-18

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds hapten, hapten-carrier complex, or...

424180, 536 27, A61K 3170

Patent

active

043691773

ABSTRACT:
A stable composition of S-adenosyl-L-methionine is disclosed which includes a salt of S-adenosyl-L-methionine and a pharmaceutically acceptable, water-soluble salt of a bivalent or trivalent metal. The salt of S-adenosyl-L-methionine is, for example, a salt of S-adenosyl-L-methionine with hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, phosphoric acid, formic acid, acetic acid, citric acid, tartaric acid, or maleic acid; or a double salt of S-adenosyl-L-methionine with the foregoing acids. The salt of a bivalent or trivalent metal is, for example, calcium chloride, ferric chloride, magnesium chloride, or magnesium sulfate. A process for preparing the composition is also disclosed. The composition is suitable for preparing pharmaceutical preparations of S-adenosyl-L-methionine.

REFERENCES:
patent: 3954726 (1976-05-01), Fiecchi
patent: 4109079 (1978-08-01), Kawahara et al.
patent: 4242505 (1980-12-01), Kawahara et al.

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