Stable composition of interleukin-2 and human serum albumin

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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514 21, 514 8, 514 12, 435 68, 435948, 530828, A61K 4502, A61K 3702

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048125571

ABSTRACT:
The present invention provides an interleukin-2 composition which comprises human serum albumin, a reducing compound or a combination thereof and is adjusted as showing pH of 3 to 6 as a solution. The composition of the present invention is characterized in that interleukin-2 activity is minimized during storage and in the processes of freezing and lyophilization.

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Mier, James W., et al., Journal of Immun., vol. 128, (3), 3/82.
Rubin et al. PNAS, 77, No. 10, 5928-5932 (1980).
Taniguchi et al., Nature, 302, 305-310 (1983).

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