Stable composition of interleukin-2 and albumin

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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435 68, 435948, 514 2, 514 8, 514 12, 514 21, 530828, A61K 4502, A61K 3702

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active

046458301

ABSTRACT:
The present invention provides an interleukin-2 composition which comprises human serum albumin, a reducing compound or a combination thereof and is adjusted as showing pH of 3 to 6 as a solution. The composition of the present invention is characterized in that interleukin-2 activity is minimized during storage and in the processes of freezing and lyophilization.

REFERENCES:
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patent: 4462940 (1984-07-01), Hanisch et al.
patent: 4490289 (1984-12-01), Stern
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patent: 4572798 (1986-02-01), Koths et al.
patent: 4578335 (1986-03-01), Urdal et al.
patent: 4604377 (1986-08-01), Fernandes et al.
Rubin et al, PNAS, 77, No. 10, 5928-5932 (1980).
Nature, 302, 305-310 (1983), Taniguchi et al.

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