Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-08-01
1999-12-07
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435178, 435 681, 435174, 435966, 435967, 435972, 5483037, 530367, C07D23502, C12N 1100, C12N 1110, G01N 33569
Patent
active
059981555
ABSTRACT:
Compositions and methods for avidin or protein having affinity for biotin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels for binding biotin and may include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the composition during lyophilization and terminal sterilization processes. The compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomers useful for fibrin sealants.
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Burton Steven James
Edwardson Peter A. D.
Pearson James C.
E.R. Squibb & Sons, Inc.
Furman Jr. Theodore R.
Kilcoyne John M.
Naff David M.
Ware Deborah K.
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