Stable carotenoid emulsions suitable for parenteral administrati

Drug – bio-affecting and body treating compositions – Dispersion or emulsion – Oil-water type

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514938, 514975, 424400, 252311, 252312, A61K 9107, A61K 4732, A61K 4718

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active

059256842

ABSTRACT:
A stable oil-in-water emulsion suitable for parenteral administration, containing less than 10% by weight lecithin, consisting of an aqueous phase and of an oil phase which is very finely dispersed by means of a physiologically tolerated emulsifier and which contains at least one carotenoid and is based on a physiologically tolerated oil or fat and comprises as emulsifier polyoxyethylene/polyoxypropylene block polymers and/or lecithin, and wherein the carotenoid is present in the oil phase in a concentration above the saturation solubility of the carotenoid in the oil or fat at room temperature.

REFERENCES:
patent: 4107343 (1978-08-01), Petricca
patent: 5075113 (1991-12-01), DuBois
patent: 5350773 (1994-09-01), Schweikert et al.
patent: 5472706 (1995-12-01), Friedman et al.
Grant & Hackh's Chemical Dictionary, 5th Ed p. 116.
Journal of Pharmaceutical Sciences, APhA, Benita et al., vol. 82, No. 11.
Chem. Abstr. J5 8162-517.
Chem. Abstr. JO 4026-670.
Biochimica et aBiophysica Acta, 111 (1992) 135-138, Grolier et al.

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