Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-06-27
1999-06-22
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, A61F 202
Patent
active
059141220
ABSTRACT:
A stable budesonide solution with a pH not exceeding 6.0 in which the budesonide is dissolved in a solvent which may be water, an alcohol such as ethanol, isopropanol or propylene glycol, or a water/alcohol mixture. The solution preferably also contains a stabilizer such as sodium ethylenediaminetetraacetic acid, cyclodextrins or mixtures thereof. The stable budesonide solution is useful as the active ingredient in a rectal enema or a rectal foam.
REFERENCES:
patent: 4383992 (1983-05-01), Lipari
patent: 5725872 (1998-03-01), Stamm et al.
Atemwegs-Und Lungenkrankheiten (20)7, 381-382 (1994), J. Derbacher et al, "Physikalische Eigenschaften . . . ".
J. Pharm. Sci., 84(6), 677-681 (1995) H. Nolen et al, "Budesonide-Beta-D-Glucuronide . . . ".
Kuhn Reimund
Otterbeck Norbert
Azpuru Carlos
Dr. Falk Pharma GmbH
Meller Michael N.
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