Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2008-04-29
2008-04-29
Lilling, Herbert J. (Department: 1657)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S074000, C435S135000, C528S310000, C528S328000
Reexamination Certificate
active
07364879
ABSTRACT:
The present invention relates to a method for the production of a stable biodegradable, high water absorbable γ-polyglutamic acid (γ-PGA) hydrogel by directly cross-linking(A) a γ-polyglutamic acid (γ-PGA), a γ-polyglutamate, or a mixture thereof, and optionally a polysaccharide containing a carboxylic and/or carboxylate group, an amino acid, or a mixture thereof; and/or(B) a microbial culture broth containing a γ-polyglutamic acid (γ-PGA), a γ-polyglutamate, or a mixture thereof, and optionally a polysaccharide containing a carboxylic and/or carboxylate group, an amino acid, or a mixture thereof, with a cross-linker comprising a compound having three or more functional groups or a mixture of a compound having three or more functional groups and a compound having two functional groups,wherein each of the functional groups can react with a carboxylic group (—COOH), carboxylate group (—COO−), aldehyde group (—CHO), hydroxyl (—OH), carbonyl group (—CO), sulfone group (—SO2), amino group (—NH2) or nitro group (—NO2), or a mixture thereof.The present invention further relates to a stable biodegradable, high water absorbable γ-polyglutamic acid (γ-PGA) hydrogel and its uses.
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Ho Guan-Huei
Yang Kung-Hsiang
Yang Tou-Hsiung
Lilling Herbert J.
Scully , Scott, Murphy & Presser, P.C.
Tung Hai Biotechnology Corporation
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