Stable bioactive somatotropins

Details Stable bioactive somatotropins Stable bioactive somatotropins

1988-09-12

1992-01-07

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 514 8, 530399, 530335, 530336, 530344, 530324, A61K 3736, C07K 710, C07K 1300

Patent

active

050792300

ABSTRACT:
The present invention provides a stable and bioactive somatotropin which has its small-loop sulfhydryl groups derivatized and a method for producing the small-loop derivatized somatotropin. The small-loop derivatized somatotoropin is stable during long term storage, i.e. it forms very few dimers, oligomers, and aggregates which inactivate the somatotropin, and has a bioactivity equal to or greater than that of the non-derivatized somatotropin.

REFERENCES:
patent: 3853832 (1974-11-01), Li
patent: 4332717 (1982-06-01), Kanaoka et al.
patent: 4604359 (1986-08-01), Goeddel et al.
patent: 4620948 (1986-11-01), Builder et al.
patent: 4766205 (1888-08-01), Ghosh-Dastidar

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