Stable benzimidazole formulation

Details Stable benzimidazole formulation Stable benzimidazole formulation

2007-08-14

2007-08-14

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S400000, C424S464000, C424S465000, C424S489000, C424S493000, C424S494000

Reexamination Certificate

active

10018992

ABSTRACT:
A stable composition with a benzimidazole derivative, such as Omeprazole, which does not contain a separating layer between the active compound and an enteric coating layer. Instead, the enteric coating layer is applied as a solution with a pH value of at least 6.5, and more preferably in a range of from about 7 to about 10, directly to the benzimidazole derivative substrate. This solution, with the optional addition of a plasticizer, can be directly coated onto the substrate without any necessity for an intermediate layer. Furthermore, in this pH range, the enteric coating is optionally applicable in an aqueous solution, thereby obviating the need for organic solvents for dissolving the enteric coating material. The resultant formulation maintains the stability of the benzimidazole derivative during storage and at the same time protects the product during passage through the acidic environment of the stomach. The problem of interaction between the enteric coat and the alkaline core is thus completely eliminated as the enteric coat at this stage is no longer acidic.

REFERENCES:
patent: 5817338 (1998-10-01), Bergstrand et al.
patent: 6013281 (2000-01-01), Lundberg et al.
patent: 6149942 (2000-11-01), Scheiwe et al.
patent: 6228400 (2001-05-01), Lee et al.
patent: 6623759 (2003-09-01), Heese et al.
patent: WO 99/27917 (1999-06-01), None

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