Stable avidin composition

Details Stable avidin composition Stable avidin composition

1995-11-09

1997-11-25

Naff, David M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 681, 435174, 435177, G01N 3353, C12P 2106, C12N 1102

Patent

active

056911521

ABSTRACT:
Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. These compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants.

REFERENCES:
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patent: 4794082 (1988-12-01), Sigler
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patent: 5168049 (1992-12-01), Meade et al.
patent: 5306824 (1994-04-01), Powers et al.
Bayer and Wilchek, Journal of Chromatography, "Application of avidinbiotin technology to affinity-based separations, " 510 (1990) pgs. 3-11.

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