Stable aqueous preparation

Details Stable aqueous preparation Stable aqueous preparation

1991-08-29

1993-02-09

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514912, 514725, A61K 3107

Patent

active

051853728

ABSTRACT:
Presented is a stable aqueous preparation for ophthalmic topical administration containing vitamin A or a vitamin A derivative having vitamin A activities to be used for the treatment of dry eye syndrome characterized in that it contains a buffering component selected from the group consisting of phosphoric acid, boric acid, citric acid, glutamic acid, .epsilon.-aminocaproic acid and the alkali metal salts thereof, a non-ionic surfactant and a chelating agent, that its acidity is adjusted in the range of pH 5 to pH 8, and that it is filled in a tight container made of polypropylene or polyethylene terephthalate.

REFERENCES:
patent: 5032392 (1991-07-01), Varma
Remington's Pharmaceutical Sciences, Fifteenth Edition. 1975. p. 1467.
Physician's Desk Reference for Ophthamology, 16 Edition, 1988. pp. 204, 87.

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