Stable aqueous FK506 standards

Details Stable aqueous FK506 standards Stable aqueous FK506 standards

1993-06-02

1994-08-16

Housel, James C.

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

436 10, 436 17, 436 18, G01N 3100

Patent

active

053386841

ABSTRACT:
A stabilized, aqueous composition containing FK506. FK506 degrades rapidly in most aqueous matrices. The rate of degradation is decreased in the presence of unfixed blood cells or fragments of blood cells from human or animal sources. A number of matrices using blood components are possible. Blood can be used directly or the blood cells can be lysed. The blood is diluted with a solution of an alkali halide.

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Christians, et al., Specific and Sensitive Measurement of FK506 and Its Metabolites Blood and Urine of Liver-Graft Recipients, Clin. Chem. 38/10, pp. 2025-2032 (1992).
Murthy, et al., Radioreceptor Assay for Quantifying FK-506 Immunosuppressant in Whole Blood, Clin. Chem. 38/7, pp. 1307-1310 (1992).

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