Stable aqueous carbon sol composition for determining analyte

Details Stable aqueous carbon sol composition for determining analyte Stable aqueous carbon sol composition for determining analyte

1995-10-20

1997-06-24

Knode, Marian C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

252302, 435 71, 435 72, 435962, 435970, 435 6, 436518, 436810, G01N 33551

Patent

active

056416890

ABSTRACT:
This invention relates to a composition for use in a method for determining the presence or amount of an analyte in a sample comprising a labeled constituent consisting of an aqueous carbon sol which is stable in the absence of a stabilizing substance. The colloidal carbon particles have directly conjugated to their surface a binding component which specifically binds to the analyte and the resulting analyte/carbon particle complex is used as an indication of the presence or amount of analyte in the sample. The grade of carbon used satisfies the condition V>0 wherein V is a linear predictor value according to the formula V=-138.954-0.987.times.DBP+15,609.times.VC+3.994.times.PPD, wherein DBP is the dibutylphthalate adsorption in ml/100 g, as determined according to DIN 53601; VC is the volatile content in %, as determined according to DIN 53552; and PPD is the average primary particle diameter in nanometers.

REFERENCES:
patent: 5529901 (1996-06-01), VanDorn et al.
T. Waller, "The india-ink immunoreaction: a method for the rapid diagnosis of encephalitozoonosis", Laboratory Animals, vol. 11, pp. 93-97, (1977).
P. Geck, "India-Ink Immuno-Reaction for the Rapid Detection of Enteric Pathogens", Acta Microbiol. Acad.Sci. Hung., vol. 18, pp. 191-196 (1971).
N.R. Berguist et al., "A Novel Simple Immunoassay for Rapid Detection of Human IgG antibodies to Toxoplasma gondil", Journal of Immunological Methods, vol. 61, pp. 339-344 (1983).

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