Stable, aqueous alfa interferon solution formulations

Details Stable, aqueous alfa interferon solution formulations Stable, aqueous alfa interferon solution formulations

1994-10-11

1998-06-16

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

A61K 3821

Patent

active

057665826

ABSTRACT:
Process for making stable aqueous solution formulations containing alfa-type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride as a tonicity agent, and m-cresol as an antimicrobial preservative and which maintain high chemical, physical and biological stability of the alfa interferon for an extended storage period of at least 24 months are disclosed.

REFERENCES:
patent: 4496537 (1985-01-01), Kwan
patent: 4606917 (1986-08-01), Eppstein
patent: 4675183 (1987-06-01), Kato et al.
patent: 4680175 (1987-07-01), Estis et al.
patent: 4847079 (1989-07-01), Kwan
patent: 4857316 (1989-08-01), Eppstein
patent: 5266310 (1993-11-01), Mundorf et al.
patent: 5503827 (1996-04-01), Woog et al.
Derwent Abstract, Database WPI, Derwent AN 87-018978; Class B04; Derwent Publications, Ltd. London, GB; Abstract of Japanese published patent appln. JP, A, 61277633 (Toray Industries, Inc.); published Dec. 8, 1986.
Derwent Abstract, Database WPI, Derwent AN 84-285358; Class B04; Derwent Publications Ltd., London, G.B.; Abstract of Japanese Published Patent Appln. JPA 59176216 (Sumitomo Chemical KK); published Oct. 5, 1984.

Affiliated with

Also associated with

Rating

Stable, aqueous alfa interferon solution formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable, aqueous alfa interferon solution formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable, aqueous alfa interferon solution formulations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1721826