Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1986-12-31
1989-09-05
Terapane, John F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424404, 424451, 424453, 424456, 264 41, A61K 1300
Patent
active
H00006726
ABSTRACT:
In accordance with the present invention an antifungal capsule formulation providing enhanced stability for antifungal agents subject to oxidative degradation, e.g. nystatin, is disclosed. The new formulation comprises an antifungal agent, in an amount of from about 0.1 to about 50 percent by weight of the total formulation; and a nonaqueous carrier, throughout which said agent is uniformly dispersed.
Additionally, an antifungal capsule formulation is disclosed wherein thixotropic properties are imparted to the drug carrier system by addition of a gelling agent, such as silicon dioxide. Such thixotropic properties are desired to promote and prolong adhesion of the drug system to the vaginal mucosa in the treatment of vaginal fungal invections.
A low temperature method for fabricating capsules employing such a formulation is also disclosed, said method comprising forming a slurry of the antifungal agent and a nonaqueous liquid carrier, adding a gelling agent, if desired, to the so-formed slurry sufficient to form a thixotropic gel, and encapsulating said gel.
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Baxter Thomas H.
Dalvi Umesh G.
E. R. Squibb & Sons Inc.
Furman Jr. Theodore R.
Metzmaier Daniel
Terapane John F.
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