Stable antifungal capsule formulation

Details Stable antifungal capsule formulation Stable antifungal capsule formulation

1986-12-31

1989-09-05

Terapane, John F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424404, 424451, 424453, 424456, 264 41, A61K 1300

Patent

active

H00006726

ABSTRACT:
In accordance with the present invention an antifungal capsule formulation providing enhanced stability for antifungal agents subject to oxidative degradation, e.g. nystatin, is disclosed. The new formulation comprises an antifungal agent, in an amount of from about 0.1 to about 50 percent by weight of the total formulation; and a nonaqueous carrier, throughout which said agent is uniformly dispersed.
Additionally, an antifungal capsule formulation is disclosed wherein thixotropic properties are imparted to the drug carrier system by addition of a gelling agent, such as silicon dioxide. Such thixotropic properties are desired to promote and prolong adhesion of the drug system to the vaginal mucosa in the treatment of vaginal fungal invections.
A low temperature method for fabricating capsules employing such a formulation is also disclosed, said method comprising forming a slurry of the antifungal agent and a nonaqueous liquid carrier, adding a gelling agent, if desired, to the so-formed slurry sufficient to form a thixotropic gel, and encapsulating said gel.

REFERENCES:
patent: 3421282 (1969-01-01), Hasegawa et al.
patent: 4053489 (1977-10-01), Wirth
patent: 4250169 (1981-02-01), Hosoi et al.
patent: 4291062 (1981-09-01), Leigh et al.
patent: 4404216 (1983-09-01), Richardson
patent: 4419352 (1983-12-01), Cox et al.
patent: 4542020 (1985-09-01), Jackson et al.
patent: 4551148 (1985-11-01), Riley, Jr. et al.

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