Stable and bioactive modified porcine somatotropin and pharmaceu

Details Stable and bioactive modified porcine somatotropin and pharmaceu Stable and bioactive modified porcine somatotropin and pharmaceu

1990-07-16

1998-12-15

Ulm, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, 930120, 435 694, A61K 3827, C07K 1461, C12N 1518

Patent

active

058496947

ABSTRACT:
The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a method for producing such a small-loop modified somatotropin. Also provided by the present invention are DNA sequences coding for such small-loop modified somatotropins, plasmids containing such sequences, and organisms containing such plasmids. Furthermore, pharmaceutical compositions including small-loop modified somatotropins and methods for using such pharmaceutical compositions are disclosed.

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Abdel-Megvid et al. Proc Natl Acad Sci USA 84:6434(1987).
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