Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1993-10-01
1995-03-28
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, C07C40100
Patent
active
054017335
ABSTRACT:
The invention relates to the compounds 1,25-dihydroxy-16-ene-24-oxo-cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol which stimulate differentiation of HL-60 cells, rendering them useful as an agent for the treatment of neoplastic diseases such as leukemia, and also decrease proliferation of human keratinocytes, rendering them useful as an agent for the treatment of hyperproliferative disorders of the skin such as psoriasis.
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McLane John A.
Reddy Satyanarayama G.
Uskokovic Milan R.
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Kestler Kimberly J.
Reddy Satyanarayama G.
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