Stabilizing solutions for proteins and peptides

Details Stabilizing solutions for proteins and peptides Stabilizing solutions for proteins and peptides

1995-03-07

2000-12-26

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, 530350, 530362, 530363, A61K 3800, C07K 1400

Patent

active

061659819

ABSTRACT:
Disclosed are compositions for stabilizing proteins and fragments of the proteins. The composition contains buffer, salt, reducing agents, chelating agents and stabilizing proteins. The composition may be used to prepare highly stable diagnostic calibrators or controls and is particularly useful for calibrators or controls for cardiac markers such as troponin.

REFERENCES:
patent: 4931385 (1990-06-01), Block et al.
patent: 5217890 (1993-06-01), Dagget
Diagnosis of Perioperative Myocardial Infarction with Measurement of cardiac Troponin I. Adams et al. New England Journal of Medicine 330: 670-674, Mar. 10, 1994.
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Troponin I Found Beneficial for Non-cardiac Surgery Patients. Kahn, J. Clin. Chem. News vol. 20, No. 5, May 1994.
Molecular cloning of human cardiac troponin I using polymerase chain reaction. FEBS 08842, vol. 270, No. 1,2 Sep. 1990.
Cardiac Troponin I. A Marker with High Specificity for Cardiac Injury. Adams et al. Circulation, vol. 88, No. 1, Jul. 1993.
Use of Cardiac Troponin I to Diagnose Perioperative Myocardial Infarction in Coronary Artery Bypass Grafting. Clin. Chem. 40/11, 2066-2070 (1994). Mair et al.
Myoglobin Fluormetric Enzyme Immunoassay, Baxter Diagnostics Inc.
CK-MB Fluorometric Enzyme Immunoassay. Baxter Diagnostic Inc.
Cardiac T.TM. Elisa Troponin T. Boehringer Mannheim Corp.
Elisa Troponin-T. Boehringer Mannheim Corp.
Calbiochem Catalogue, 1994-1995, Albumins, Bovine Serum; Selecting a BSA for Your Application. Fibroblast Growth Factor, Basic Human Recombinant . . . see composition of sterile filtered Solution. Creatitine Phosphokinase, see soluite it is provided in.
Methods of Enzymatic Analysis, vol. III:508-518, Ch. 7.4 Creatine Kinase (W. Gerhardt).
Methods of Enzymology--Guide to Protein Purification. 182:83-89, Maintaining Protein Stability, (Murray P. Deutscher).

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