Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1989-08-03
1993-01-26
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514546, 536103, A61K 3172, A61K 31215
Patent
active
051822709
ABSTRACT:
Experiments have been performed which test the stability of thymoxamine in aqueous solution at room temperature and above. It was determined that dimethyl-beta-cyclodextrin slows the hydrolysis degradation of thymoxamine while other beta-cyclodextrin analogs either accelerate the hydrolysis degradation or have no effect on the rate of hydrolysis degradation. Cytological experiments have been performed which show that chemical formulations containing thymoxamine and up to 5% by weight dimethyl-beta-cyclodextrin have the same toxicity as chemical formulations with thymoxamine alone.
REFERENCES:
Hirayama et al Chem. Pharm. Bull. 32(10) 4237-4240, 1984.
Riddell et al. Fd. Chem. Toxic 24(7) 469-471, 1986.
Knox et al Fd. Chem. Toxic 24(6) 457-463 1986.
Pagington Chemistry in Britain May, 1987 pp. 455-458.
Szejtli J. of Inclusion Phenomena 135-150, 1983.
Mizutani, et al Iyakuhin Kenkyu 18(5) 1982 pp. 1006-1016.
Prosjocimo, et al American J. of Opthamology vol. 105(3) 1988 pp. 321-322.
Bekers, et al Int. J. Pharm. 1989 52(3) 239-48 Chemical Abstracts, vol. 111, 1989 Abstract 102606e.
Szeitli, J. Inclusion Phenomena 1983 1(2), 1983 135-50 Chemical Abstracts vol. 100, 1984, Abstract 161740a.
Musson Donald G.
Olejnik Orest
Bond Robert T.
Iolab Corporation
Lambert Benjamin F.
Ward E. C.
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