Stabilizing and delivery means of biological molecules

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 424450, A61K 9127

Patent

active

058407073

ABSTRACT:
The instant disclosure relates to cochleates comprising a) a biologically relevant molecule component b) a negatively charged lipid component, and c) a divalent cation component. The cochleate has an extended shelf life, even in a desiccated state. Advantageously, the cochleate can be ingested. The biologically relevant molecule can be a polynucleotide.

REFERENCES:
patent: 4078052 (1978-03-01), Papahadjopoulos
patent: 4663161 (1987-05-01), Mannino et al.
patent: 4871488 (1989-10-01), Mannino et al.
Booser et al. Anthracycline antibiotics in cancer therapy. Drugs. 1994, vol. 47, No. 2, pp. 223-258.
Mori et al. Immunotargeting of liposomes containing lipophilic antitumor prodrugs. Pharmaceutical 1993. vol. 10, No. 4, pp. 507-514.
Liposome Technology, Second Edition, vol. 1, G. Gregoriadis, Ph.D., "Liposome Preparation and Related Techniques", published 1993 by CRC Press, Inc., (Boca Raton), pp. 67-80.
J. Exp. Med., vol. 176, issued Dec. 1992, M.D. Miller et al., "Vaccination of Rhesus Monkeys with Synthetic . . . CD8+ Cytotoxic T Lymphocytes", pp. 1739-1744.
Nature, vol. 342, issued 30 Nov. 1989, K. Deres et al., "In vivo Priming of Virus-specific Cytotoxic T Lymphocytes with Synthetic Lipopeptide Vaccine", pp. 561-564.
Gene, vol. 84, issued 1989, S. Gould-Fogerite et al., "Chimerasome-mediated Gene Transfer in vitro and in vivo", pp. 429-438.
Biochimica et Biophysica Acta, vol. 394, issued 1975, D. Papahadjopoulos et al., "Cochleate Lipid Cylinders: Formation By Fusion of Unilamellar Lipid Vesicles", pp. 483-491.
Analytical Biochemistry, vol. 148, issued 1985, S. Gould-Fogerite et al., "Rotary Dialysis: Its Application to the Preparation of Membrane Proteins", pp. 15-25.
Biotechniques, vol. 6, No. 7, 1988, Mannino & Gould-Fogerite, "Liposome Mediated Gene Transfer", pp. 682-690.
Advances in Membrane Biochemistry and Bioenergetics, 1988, Gould-Fogerite et al., "The Reconstitution of Biologically . . . Animal Cells", pp. 569-586.
Journal of Immunology, vol. 147, No. 2, 1991, Goodman-Snitkoff et al., "Role of Intrastructural/Intermolecular Help in Immunization with Peptide-Phospholipid Complexes", pp. 410-415.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Stabilizing and delivery means of biological molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilizing and delivery means of biological molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilizing and delivery means of biological molecules will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1702323

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.