Stabilizing alkylglycoside compositions and methods thereof

Details Stabilizing alkylglycoside compositions and methods thereof Stabilizing alkylglycoside compositions and methods thereof

2006-06-23

2008-09-16

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S777000

Reexamination Certificate

active

07425542

ABSTRACT:
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example insulin and Peptide T or analog thereof.

REFERENCES:
patent: 5849704 (1998-12-01), Sørensen et al.
patent: 6017883 (2000-01-01), Cooper, Jr.
patent: 7186691 (2007-03-01), Quay et al.
patent: 2005/0031549 (2005-02-01), Quay et al.
patent: 2006/0046962 (2006-03-01), Meezan et al.
patent: 2007/0111938 (2007-05-01), Pert et al.
Ahsan et al “Enhanced Bioavailability of Calcitonin Formulated with Alkylglycosides Following Nasal and Ocular Administration in Rats” 2001, Pharmaceutical Research, vol. 18. pp. 1742-1746.
Arnold et al. “Correlation of Tetradecylmaltoside Induced Increases in Nasal Peptide Drug Delivery with Morphological Changes in Nasal Epithelial Cells”, Sep. 2004, Journal of Pharmaceutical Sciences, vol. 93. pp. 2205-2213.
Bagger et al., “Nasal Bioavailability of Peptide T in Rabbits: Absorption Enhancement by Sodium Glycocholate and Glycofurol.”European Journal of Pharmaceutical Sciences14:69-74 (2001).
Pillion et al., “Insulin Delivery in Nosedrops: New Formulations Containing Alkylglycosides.”Endocrinology135(6):2386-2391 (1994).
Rosevear et al., “Alkyl Glycoside Detergents: A Simpler Synthesis and Their Effects on Kinetic and Physical Properties of CytochromecOxidase.”Biochemistry19:4108-4115 (1980).

Affiliated with

Also associated with

Rating

Stabilizing alkylglycoside compositions and methods thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilizing alkylglycoside compositions and methods thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilizing alkylglycoside compositions and methods thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3990258