Stabilizing agent for oleaginous, physiologically active substan

Details Stabilizing agent for oleaginous, physiologically active substan Stabilizing agent for oleaginous, physiologically active substan

1997-08-04

1998-12-29

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424 763, 424 764, 424438, 424442, 424451, 424464, 424488, 574560, 574578, A61K 916

Patent

active

058537619

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

This invention relates to a stabilizing agent for oleaginous, physiologically active substances and to a preparation containing the stabilizing agent.


BACKGROUND ART

Oleaginous physiologically active substances (e.g. DHA) are difficult to work with and, for the ease of ingestion, are conventionally sealed in capsules or adsorbed on a particulate substrate and over-coated. However, such products are not sufficiently stable or the resulting granules or tablets, for instance, are bulky and often not suited at all for addition to general food. To overcome the disadvantages, a calcium encrustation technology using milk calcium as a chief shell-forming material was developed (New Food Industry, 36, 9, 38-42, 1994) but even the preparations provided by this technology are unstable and give off malodors when incorporated in, for example, beverages or drinks, thus leaving the problem unsolved.


DISCLOSURE OF INVENTION

To solve the problem, the inventors of this invention did much research and as a consequence discovered that calcium gluconate is a very useful stabilizing agent for oleaginous, physiologically active substances and that by using this calcium gluconate in combination with a reticular matrix-forming agent and/or an sticking agent, very stable preparations free from the above-mentioned disadvantages can be provided.
Thus, calcium gluconate is a calcium compound of relatively high water-solubility and when 100 g of the compound is put in 1 liter of water, about 30 grams of the input compound dissolve in the water while about 70 grams remain suspended. When an oleaginous, physiologically active substance is added to this liquid and the mixture is emulsified with stirring, the calcium not dissolved in water is adsorbed on each oil globule to form a shell layer on its surface. The dissolved calcium gluconate enters and fills up the interstice between shell-formed particles. When the mixture in this condition is quickly dried, there is obtained a powdery preparation containing the oleaginous, physiologically active substance hermetically trapped or masked.
It was also found that when a reticular matrix-forming agent and/or a sticking agent is used in combination with the above-mentioned calcium gluconate, the stability of the preparation is further enhanced and when this preparation is added to a beverage, for instance, there is obtained a stable, odorless product.
The oleaginous, physiologically active substance that can be used advantageously in accordance with this invention includes a variety of oily physiologically active substances which have their own peculiar tastes and/or odors and are unstable against enzymes, oxygen, light, and heat. A typical but by no means exclusive list of such substances includes highly unsaturated fatty acids such as DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), etc., fat-soluble vitamins such as vitamin D, vitamin E, vitamin K, etc., and carotenes such as .beta.-carotene.
Now, while DHA and EPA, for instance, occur at high levels in fish oil and usually exist in the triglyceride form, the term DHA or EPA as used throughout this specification means not only DHA or EPA as such but also the corresponding glycerin ester (e.g. triglyceride), alkyl ester (e.g. ethyl ester), or other derivative.
As to DHA and EPA, purified fish oils containing 20-100% of them are commercially available and can be utilized.
The reticular matrix-forming agent that can be used in this invention phosphopeptides which are partial hydrolyzates available on digestion of casein with protease (e.g. trypsin) (CPP: CPP-I, CPP-II, CPP-III, etc.) (New Food Industry, 35, No. 9 (1993), pp. 1-8), etc.!, and polysaccharides such as pectin. Among them, each of milk calcium and CPP has both the property to form a reticular matrix and the property to function as a sticking agent as will be described hereinafter. Therefore, those substances may respectively be expected to double as a reticular matrixing agent and a sticking agent.
The sticking agent includes thicking agents (e.g. CMC,

REFERENCES:
patent: 4165392 (1979-08-01), Kawai et al.
patent: 4430356 (1984-02-01), Ohyabu et al.
Milko et al. p. 450 Calcium Gluconate, 1949.

Affiliated with

Also associated with

Rating

Stabilizing agent for oleaginous, physiologically active substan does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilizing agent for oleaginous, physiologically active substan, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilizing agent for oleaginous, physiologically active substan will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1422062