Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1997-12-18
2000-04-18
Bui, Phuong T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241991, 4242041, 4241891, 4242111, 4242171, 4242181, 4242291, 4242251, 4242781, 4242301, 4242191, 4242311, 4352351, 435236, A61K 3912, A61K 39165, C07H 304, C12N 704
Patent
active
060512385
ABSTRACT:
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.
REFERENCES:
patent: 3783098 (1974-01-01), Kalnak et al.
patent: 3915794 (1975-10-01), Zygraich et al.
patent: 3985615 (1976-10-01), Kubo
patent: 4000256 (1976-12-01), Hilleman et al.
patent: 4147772 (1979-04-01), McAleer et al.
patent: 4273762 (1981-06-01), McAleer et al.
patent: 4296204 (1981-10-01), Grabner et al.
patent: 4337242 (1982-06-01), Markus et al.
patent: 4338335 (1982-07-01), McAleer et al.
patent: 4985244 (1991-01-01), Makino et al.
patent: 5024836 (1991-06-01), McAleer et al.
Bovarnick, et al., 1950, "The Influence of Certain Salts, Amino Acids, Sugars and Proteins on the Stability of Rickettsiae," J. Bacteriol. 59: 509-522.
McAleer, et al., 1980, "Stability on storage at varous temperatures of live measles, mumps and rubella vaccines in new stabilizer," J. Biological Stand. 8:281-287.
Howell, et al., Sep., 1983, "Effect of Sucrose Phosphate and Sorbitol on Infectivity of Enveloped Viruses During Storage," J. Clin. Microbiol. 18: 658-662.
Bennett, et al. (Karger, Basel, 1991), "The Effects of Freeze-Drying on the Potency and Stability of Live Varicella Virus Vaccine," Develop. Biological Stand., vol. 74, pp. 215-221.
Burke Carl J.
Sheu Su-Pi
Volkin David B.
Bui Phuong T.
Coppola Joseph A.
Merck & Co. , Inc.
Tribble Jack L.
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