Stabilizers for fibroblast growth factors

Details Stabilizers for fibroblast growth factors Stabilizers for fibroblast growth factors

1992-04-01

1994-09-20

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530397, 530399, 514970, 514 21, 536 2621, 536 2623, 536 2626, A61K 3702, A61K 3736

Patent

active

053489411

ABSTRACT:
Medicinal compositions containing fibroblast growth factor are stabilized against loss of biological activity by including in said composition a stabilizing amount of phytic add, phosvitin, phosphate buffer, (NH.sub.4).sub.6 P.sub.4 O.sub.13, Na.sub.5 P.sub.3 O.sub.10, Na.sub.4 P.sub.2 O.sub.7 and Na.sub.3 P.sub.3 O.sub.9, adenosine tetra, tri, di and mono phosphate and related diadenosine compounds plus other single and multi-phosphorylated mono and di-nucleotides, poly-aspartic acid, poly-adenylic-guanylic add and related compounds, double stranded deoxyribonucleic add, single stranded deoxyfibonucleic acid and poly-glutamic acid. Medicinal compositions for topical use are combined with a viscous excipient such as a water soluble polysaccharide with said combination with a second stabilizier.

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