Stabilizer for polysaccharides

Details Stabilizer for polysaccharides Stabilizer for polysaccharides

1978-10-25

1980-06-03

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902

Patent

active

042062004

ABSTRACT:
For improving the stability of menningococcal polysaccharides in aqueous solution, lactose is completely or partially replaced by another compound which forms a hydrate and can be reversibly dehydrated under the conditions of lyophilization. The mixture may then be dried and/or processed to a vaccine.

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patent: 3608066 (1971-09-01), Illartein
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patent: 3743720 (1973-07-01), Fosker et al.
patent: 3859434 (1975-01-01), Jennings et al.
Tiesjema, R. H. et al., Chem. Abstr. 87:122686v (1977) of Bull. W.H.O. (1977), 55(1), 43-48, "Enhanced Stability of Meningococcal Polysaccharide Vaccines by Using Lactose as a Menstruum for Lyophilization".

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