Stabilized, water-soluble aspirin composition

Details Stabilized, water-soluble aspirin composition Stabilized, water-soluble aspirin composition

1995-11-13

1998-03-03

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514159, 424 44, A61K 3160

Patent

active

057234531

ABSTRACT:
A stabilized, essentially sodium free, alkaline and aspirin combination compound which is readily soluble in a preselected fluid, which when dissolved forms potassium acetylsalicylate. Such alkaline and aspirin combination compound consisting essentially of aspirin, having a predetermined particle size. Such aspirin being present in the alkaline and aspirin combination compound generally within a range of between about 325.0 mg and about 1,000.0 mg per unit dose. A preselected alkaline compound is present in such alkaline and aspirin combination compound generally within a range of between about 250.0 mg and about 3,000.0 mg per unit dose. The preselected alkaline compound having a ph generally within a range of between about 8.0 and 10.0 and such preselected alkaline compound being present in this alkaline and aspirin combination compound in a molar amount which is greater than a molar amount required to neutralize the aspirin.

REFERENCES:
patent: 2297599 (1942-09-01), Wilen
patent: 3105792 (1963-10-01), White
patent: 3495001 (1970-02-01), Leonards
patent: 3903255 (1975-09-01), Gusman et al.
patent: 4687662 (1987-08-01), Schobel
patent: 4704269 (1987-11-01), Korab
patent: 4942039 (1990-07-01), Duvall et al.
patent: 5157030 (1992-10-01), Galat

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