Stabilized trinder reagent

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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435 28, G01N 3315, C12Q 128

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active

052060063

ABSTRACT:
Spontaneous aspecific coloration in so-called Trinder reagents which can alter subsequent colorimetric determinations is inhibited by adding compounds of the chelating agent class to the solution. The resultant compositions contain a peroxidase enzyme, a phenylpyrazone derivative, a compound of phenolic or aromatic amine structure and a stabilizer. Preferred stablizers are ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).

REFERENCES:
patent: Re29498 (1977-12-01), Meiattini
patent: 3992158 (1976-11-01), Przybylowicz
patent: 4716110 (1987-12-01), Wada et al.
Putz et al., Am. Jour. Med. Technology vol. 42(10) 1976. pp. 351-356.
Ziebig et al., "Investigations of the Effect of Ascorbic Acid on Glucose Determination in the GOD-PAP Method", Zentralbl. Pharm. 125, (1986) pp. 223-227.

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