Stabilized therapeutic radiopharmaceutical complexes

Details Stabilized therapeutic radiopharmaceutical complexes Stabilized therapeutic radiopharmaceutical complexes

1990-07-09

1993-06-15

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

252644, A61K 4300

Patent

active

052195562

ABSTRACT:
A method of preparing a stable, therapeutic radiopharmaceutical composition comprised of an alpha- or beta-emitting radionuclide and a ligand by lyophilizing a solution of the complex. The radionuclide preferably has a half-life of at least twelve hours. The invention also is directed to stable lyophilized radiopharmaceutical compositions prepared by this method. The invention is particularly suited to the preparation of radionuclide-labeled antibodies in a stable form which merely requires reconstitution at the point of use.

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Abstract "Radiohalogenation of Antibodies--A Review of Labeling Methods and Their Chemical Consequences, " Reynolds, J. C. at Radiolabeled Monoclonal Antibodies for Imaging and Therapy, Jul. 20-Aug. 1, 1986, Italy.
S. J. Mather and B. G. Ward, J. Nuclear Medicine 28: 1034-1036 (1987).
C. F. Meares et al., Analytical Biochemistry 142: 68-78 (1984).
B. W. Wistow et al., J. Nuclear Medicine 18: 455-461 (1977).

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