Stabilized superoxide dismutase (SOD) composition

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Stabilized enzymes or enzymes complexed with nonenzyme

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 944, 424 941, A61K 3844

Patent

active

054646146

ABSTRACT:
A stabilized superoxide dismutase (SOD) composition contains as additives cyclodextrin, preferably hydroxypropyl-.beta.-cyclodextrin, and either a sugar or a sugar alcohol, preferably mannitol.
Freeze-dried formulations with the composition according to the invention yield clear solutions with a high enzymatic activity on resolvation.

REFERENCES:
patent: 4346174 (1982-08-01), Yasuda et al.
patent: 5024998 (1991-06-01), Bodor
patent: 5246847 (1993-09-01), Hartman et al.
patent: 5260204 (1993-11-01), Heckl et al.
patent: 5298410 (1994-03-01), Phillips et al.
European Search Report for Application No. 93118801.5 dated Oct. 4, 1994 (3 pages).
"Anti-Inflammatory Compositions Containing Orgotein--With Excess Mannitol as Potentiator", BE-891160, available in Derwent World Patent Index, STN (Abstract).
Barra et al., "The Primary Structure of Human Liver Manganese Superoxide Dismutase", J. Biol. Chem. 259:12595-12601 (Oct. 25, 1984).
Brewster et al., "Use of 2-Hydroxypropyl-.beta.-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs", Pharm. Res. 8:792-795 (1991).
Gorecki et al., "Recombinant Human Superoxide Dismutases: Production and Potential Therapeutical Uses", Free Rad. Res. Comms. 12-13:401-410 (1991).
Hartz & Deutsch, "Subunit Structure of Human Superoxide Dismutase", J. Biol. Chem. 247:7043-7050 (Nov. 10, 1972).
Hora et al., "Lyophilized Formulations of Recombinant Tumor Necrosis Factor", Pharm. Res. 9:33-36 (1992).
Jabusch et al., "Some Sulfhydryl Properties and Primary Structure of Human Erythrocyte Superoxide Dismutase", Biochem. 19:2310-2316 (1980).
Lee & Fennema, "Ability of Cyclodextrins to Inhibit Aggregation of .beta.-Casein", J. Agric. Food Chem. 39:17-21 (1991).
Marres et al., "Nucleotide sequence analysis of the nuclear gene coding for manganese superoxide dismutase of yeast mitochondria, a gene previously assumed to code for the Rieske iron-sulfur protein", Eur. J. Biochem. 147:153-161 (1985).
McCord & Fridovich, "Superoxide Dismatase: An Enzymic Function for Erythrocuprein (humocuprein)", J. Biol. Chem. 244:6049-6055 (Nov. 25, 1969).
McCord et al., "A Manganese-Containing Superoxide Dismutase from Human Liver", Superoxide and Superoxide Dismutases, Academic Press, London, pp. 129-138 (1977).
Nimrod et al., "Recombinant Human Manganese Superoxide Dismutase (r-hMnSOD) is a Potent Anti-Inflammatory Agent", Med. Biochem. & Chem. Aspects of Free Raficals, pp. 743-746 (1989).
Pitha et al., "Molecular Encapsulation of Drugs by Cyclodextrins and Congeners", Controlled Drug Delivery (Bruck, S. D., ed.) vol. I, CRC Press, Boca Raton, Fla., pp. 125-148 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Stabilized superoxide dismutase (SOD) composition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized superoxide dismutase (SOD) composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized superoxide dismutase (SOD) composition will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-195692

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.