Stabilized steroid composition and method for its preparation

Details Stabilized steroid composition and method for its preparation Stabilized steroid composition and method for its preparation

2008-05-27

2008-05-27

Hui, San-ming (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S181000

Reexamination Certificate

active

10762652

ABSTRACT:
Stabilized 17-substituted hydrocortisone containing compositions and methods of manufacture. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by introducing an omega-6. acid in the form of linoleic acid into the skin preparation. Preferably, the linoleic acid is added as a component of refined safflower oil. The omega-6 acid has been found to be an effective way of preventing the isomerization of hydrocortisone 17-butyrate into the undesirable isomer HC21-B.

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Remington's Pharmaceutical Sciences, 18th ed., 1990, pp. 956-971.

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