Stabilized steroid composition and method for its preparation

Details Stabilized steroid composition and method for its preparation Stabilized steroid composition and method for its preparation

2011-07-19

2011-07-19

Hui, San-Ming (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

active

07981877

ABSTRACT:
Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by including an omega-6 acid component in the form of a free acid or as a compound such as an ester. Specifically disclosed are methods for preventing the isomerization of hydrocortisone 17-butyrate into hydrocortisone 21-butyrate through the use of safflower oil.

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Remington's Pharmaceutical Sciences: Eighteenth Edition; 1990; pp. 956-971.

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