Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1993-08-11
1995-10-03
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
556137, A61K 3128, C07F 1500
Patent
active
054552702
ABSTRACT:
Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carrier with air or oxygen and, optionally, blanketing the headspace with air or oxygen.
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Agharkar Sheeram
Bogardus Joseph B.
Kaplan Murray A.
Perrone Robert K.
Phusanti Lawan
Bristol-Myers Squibb Co.
Killos Paul J.
Nolan Sandra M.
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