Stabilized soluble glycoprotein trimers

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C424S185100, C424S192100, C424S208100, C530S300000

Reexamination Certificate

active

11126797

ABSTRACT:
The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.

REFERENCES:
patent: 6140059 (2000-10-01), Schawaller
patent: 7022324 (2006-04-01), Binley et al.
patent: WO 99/16883 (1999-04-01), None
Gorelick et al. Journal of Virology, 1990, vol. 64, p. 3207-3211.
Yang et al., J. of Virol., vol. 74 (No. 10), p. 4746-4754, (May 2000).
Binley et al., J. of Virol., vol. 74 (No. 2), p. 627-643, (Jan. 2000).
Weissenhorn et al., Nat'l Acad. of Science, vol. 94, p. 6065-6069, (Jun. 1997).
Nautiyal et al., Biochemistry, vol. 34 (No. 37), pp. 11645-11651, (Sep. 1995).
Richmond et al., J. of Virol., vol. 72 (No. 11), p. 9092-9100, (Nov. 1998).
Yang et al., J. of Virol., vol. 74 (No. 12), p. 5716-5725, (Jun. 2000).
Yang et al., J. of Virol., vol. 75 (No. 3), p. 1165-1171, (Feb. 2001).
Burgess et al., J. of Cell Bio., vol. 111, p. 2129-2138, (1990).
Lazar et al., Molecular and Cellular Biology, vol. 8 (No. 3), p. 1247-1252, (1988).
Tao et al., The Journal of Immunology, vol. 143 (No. 8), p. 2595-2601, (1989).
Farzan et al., J. of Virol., vol. 72 (No. 9), p. 7620-7625, (Sep. 1998).

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