Stabilized soluble glycoprotein trimers

Details Stabilized soluble glycoprotein trimers Stabilized soluble glycoprotein trimers

2008-09-30

2008-09-30

Campell, Bruce (Department: 1648)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C424S185100, C424S192100, C424S208100, C530S300000

Reexamination Certificate

active

11126797

ABSTRACT:
The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.

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