Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2005-06-28
2005-06-28
Winkler, Ulrike (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S186100, C424S192100, C424S208100, C435S005000, C530S300000, C530S350000, C536S023400, C536S023720
Reexamination Certificate
active
06911205
ABSTRACT:
The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.
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Farzan Michael
Kwong Peter D.
Sodroski Joseph G.
Wyatt Richard
Yang Xinzhen
Dana-Farber Cancer Institute Inc.
Nixon & Peabody LLP
The Trustees of Columbia University
Winkler Ulrike
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